Drug Uses

Zyloprim reduces the production of uric acid in your body. Zyloprim is used to treat gout, increased levels of uric acid caused by cancer treatment, and kidney stones that are caused by high levels of uric acid.

How Taken

Zyloprim comes as a tablet to take it orally. It usually is taken once a day, preferably after a meal. Drink at least eight glasses of water or other fluids each day while taking Zyloprim unless directed to do otherwise by your doctor. Avoid excessive amounts of vitamin C supplements or fruit juice while taking Zyloprim. Too much vitamin C may increase your chance of developing kidney stones.

Warnings/Precautions

Before taking Zyloprim, tell your doctor if you have kidney or liver disease. You may need a lower dose of Zyloprim or special monitoring during your therapy. Zyloprim is in the FDA pregnancy category C. This means that it is not known whether Zyloprim will harm an unborn baby. Do not take Zyloprim without first talking to your doctor if you are pregnant. Zyloprim passes into breast milk. Do not take Zyloprim without first talking to your doctor if you are breast-feeding a baby.

Missed Dose

Take the missed dose as soon as you remember. However, if it is almost time for your next dose, skip the dose you missed and take only your next regularly scheduled dose. Do not take a double dose of this medication.

Possible Side Effects

If you experience any of the following serious side effects, stop taking Zyloprim and seek emergency medical attention: an allergic reaction (difficulty breathing; closing of your throat; swelling of your lips, tongue, or face; or hives); blood in your urine or pain when you urinate; a rash; eye irritation; fever, chills, or joint aches; or severe nausea or vomiting. Other, less serious side effects may be more likely to occur. Continue to take Zyloprim and talk to your doctor if you experience upset stomach or diarrhea; headache, dizziness, or drowsiness; or an acute attack of gouty arthritis. Side effects other than those listed here may also occur. Talk to your doctor about any reaction that seems unusual or that is especially bothersome.

Storage

Store at 15-25°C (59-77°F) in a dry place and protect from light.

Overdose

Seek emergency medical attention. Symptoms of Zyloprim overdose are not known.

More Information

Use caution when driving, operating machinery, or performing other hazardous activities. Zyloprim may cause drowsiness. If you experience drowsiness, avoid these activities. Avoid alcohol. It may worsen your condition. Follow your doctor's recommendations about diet.

Disclaimer

This drug information is for your information purposes only, it is not intended that this information covers all uses, directions, drug interactions, precautions, or adverse effects of your medication. This is only general information, and should not be relied on for any purpose. It should not be construed as containing specific instructions for any particular patient. We disclaim all responsibility for the accuracy and reliability of this information, and/or any consequences arising from the use of this information, including damage or adverse consequences to persons or property, however such damages or consequences arise. No warranty, either expressed or implied, is made in regards to this information.

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Colchicine, a water-soluble alkaloid found in the autumn crocus, blocks or suppresses cell division by inhibiting mitosis, the division of a cell's nucleus. Specifically, it inhibits the development of spindles as the nuclei are dividing. Normally, the cell would use its spindle fibers to line up its chromosomes, make a copy of them, and divide into two new cells with each daughter cell having a single set of chromosomes. With colchicine present, the spindle fibers don't form, and so the cell can't move its chromosomes around. The cell may end up copying some or all of the chromosomes anyway, but can't parcel them out into new cells, and so it never divides.
Because cancer cells divide much more rapidly than normal cells, cancers are more susceptible to being poisoned by mitotic inhibitors such as colchicine, paclitaxel, and the Vinca alkaloids.
However, colchicine has proven to have a fairly narrow range of effectiveness as a chemotherapy agent, so its only FDA-approved use is to treat gout (it is one of the active ingredients of ColBenemid, anti-gout tablets marketed by Merck & Co.), though it is also occasionally used in veterinary medicine to treat cancers in some animals. It is also used as an antimitotic agent in cancer research involving cell cultures.
Gout is an illness caused by faulty uric acid metabolism in which excess uric acid is turned into crystals of sodium urate, which are then deposited in the joints (most often in the big toe), causing inflammation and pain. Researchers aren't sure exactly how colchicine works against gout, but it does seem to reduce the frequency of severe attacks and relieves residual pain.
As far as side effects go, colchicine can cause a temporary reduction in the number of leukocytes (white blood cells) in the bloodstream; afterward, the leukocyte count can rebound to abnormally high levels. Colchicine also causes teratogenic birth defects in lab animals, and so pregnant women with gout should not use colchicine-containing drugs.
Colchicine poisoning resembles arsenic poisoning; the symptoms (which, because it is a mitotic poison, occur 2 to 5 hours after the toxic dose has been ingested) include burning in the mouth and throat, diarrhea, stomach pain, vomiting, and kidney failure. Death from respiratory failure often follows. A specific antidote doesn't exist, so treatment typically involves giving the victim activated charcoal or pumping the stomach.

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