Drug Uses

Xenical is used to help obese people who fit certain weight and height requirements lose weight and maintain weight loss. Xenical works in your intestines, where it blocks some of the fat you eat from being absorbed. This undigested fat is then eliminated in your bowel movements. Use Xenical together with a reduced-calorie diet. The weight management effects of Xenical continue only as long as you are taking it.

How Taken

Xenical comes in a capsule to take it orally. It is usually taken tree times a day with food. Take Xenical exactly as directed. Do not take more or less of it or take it more often than prescribed by your doctor. Xenical should be given with meals. A diet consisting of daily intake of fat (30% of total calories), carbohydrates, and protein should be distributed evenly over 3 main meals.

Warnings/Precautions

Do not take Xenical without first talking to your doctor if you have a chronic malabsorption syndrome, or gallbladder problems. You may not be able to take Xenical if you have any of the conditions listed above. Before taking Xenical, talk to your doctor if you have a history of kidney stones, have diabetes, have anorexia or bulimia, take any other weight-loss medicine, or take cyclosporine. You may not be able to take Xenical, or you may require a dosage adjustment or special monitoring during your treatment if you have any of the conditions listed above. Xenical is in the FDA pregnancy category B. This means that it is not expected to harm an unborn baby. Do not take Xenical without first talking to your doctor if you are pregnant. It is not known whether Xenical passes into breast milk. Do not take Xenical without first talking to your doctor if you are breast-feeding a baby.

Missed Dose

If you miss a dose resume taking Xenical at the next meal. Do not try to make up the loss with a double dose. The extra drug will not help.

Possible Side Effects

Stop taking Xenical and seek emergency medical attention if you experience a rare allergic reaction including shortness of breath; closing of your throat; swelling of your lips, tongue, or face; or hives. Other, less serious side effects are more likely to occur. Continue to take Xenical and talk to your doctor if you experience oily spotting, gas with discharge, an urgent need to go to the bathroom, oily or fatty stools, an oily discharge, an increased number of bowel movements, an inability to control bowel movements, or orange or brown colored oil in your stool. The bowel changes listed above are a natural effect of blocking fat and indicate that Xenical is working. They generally occur early in treatment, particularly after meals containing higher amounts of fat than are recommended. These symptoms are usually temporary and lessen or disappear as you continue treatment and keep to your recommended diet of meals containing 30% fat. Side effects other than those listed here may also occur. Talk to your doctor about any side effect that seems unusual or that is especially bothersome.

Storage

Store this medication at room temperature and out of the reach of children. Protect from moisture. Keep container tightly closed. Throw away any unused medicine after the expiration date.

Overdose

Seek emergency medical attention. Symptoms of a Xenical overdose are not known.

More Information

Xenical may decrease your body's absorption of some fat-soluble vitamins. To ensure adequate nutrition, your doctor may recommend taking a multivitamin that contain vitamins D, E, K, and beta-carotene. Take your vitamin supplement once a day, at least 2 hours before or after a dose of Xenical. Each time you take Xenical, your meal should contain no more than about 30% of calories from fat. Evenly divide your daily intake of fat, carbohydrates, and protein over three main meals a day. Talk to your doctor about following a healthy eating plan.

Disclaimer

This drug information is for your information purposes only, it is not intended that this information covers all uses, directions, drug interactions, precautions, or adverse effects of your medication. This is only general information, and should not be relied on for any purpose. It should not be construed as containing specific instructions for any particular patient. We disclaim all responsibility for the accuracy and reliability of this information, and/or any consequences arising from the use of this information, including damage or adverse consequences to persons or property, however such damages or consequences arise. No warranty, either expressed or implied, is made in regards to this information.

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he weight loss medication Xenical? (orlistat) has been shown to be significantly more effective than lifestyle changes alone in managing weight in overweight adolescents, according to new study results presented today at ECO2004, Prague, Czech Republic.
"This is good news for physicians, parents and young people struggling with teenage overweight and obesity. Excess weight in adolescents has short and long-term effects on health, most notably increased risk of high blood pressure, raised cholesterol and the development of type 2 diabetes. In addition, childhood and adolescent obesity is closely associated with earlier mortality in adulthood," said principal study investigator Professor Jean-Pierre Chanoine, British Columbia's Children's Hospital, Vancouver, Canada. "Obesity is a global epidemic, and is now the most common teenage health problem in the developed world. These study results demonstrate Xenical's benefits as an effective and safe therapy that will contribute to helping this important patient group."
The one year study, involving 539 adolescents aged 12 to 16, evaluated the efficacy and safety of Xenical in conjunction with lifestyle changes (a mildly reduced-calorie diet, exercise and behavioural therapy) compared to the efficacy of lifestyle changes alone.
Study results showed that adolescents treated with Xenical1 had:
* significantly greater reduction in fat mass (- 2.4 kg vs. - 0.38kg) (p=0.033).
* significantly greater decrease in waist circumference (- 2.39% vs. - 0.87%) (p=0.013)
* significantly reduced BMI compared with adolescents receiving lifestyle changes alone ( -0.67 kg/m2 vs. + 0.17 kg/m2) (p=0.001)
In addition:
* a greater proportion of Xenical treated adolescents achieved a =5% and =10% decrease in BMI (27% vs. 16% and 13.3% vs. 4.5% respectively)
* Xenical was well tolerated and reported adverse events were similar to those seen in adults.
In December 2003 the U.S. Food and Drug Administration (FDA) approved labelling for use of Xenical in the management of obese adolescents aged 12 to 16 years. This was the first approval of its kind for a prescription weight-loss treatment.
This new study further complements the outstanding bank of data illustrating Xenical's efficacy, safety and tolerability in adults. In addition to significant weight reduction, Xenical has also been shown to reduce the risk of developing diabetes (in the landmark XENDO Study) and improve cardiovascular risk factors in adults who are overweight or obese. Xenical has a long-term safety profile unmatched in the field of weight loss.

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