Drug Uses

Naprosyn is indicated for the treatment of rheumatoid arthritis, osteoarthritis, juvenile arthritis, ankylosing spondylitis, tendonitis and bursitis, and acute gout. It is also indicated in the relief of mild to moderate pain, and for the treatment of primary dysmenorrhea. Naprosyn Suspension is recommended for juvenile rheumatoid arthritis in order to obtain the maximum dosage flexibility based on the patient's weight.

How Taken

Naprosyn comes as a regular tablet, an extended-release tablet, and a liquid to take by mouth. It usually is taken twice a day for arthritis, every 8 hours for gout, and once a day (extended-release tablets) or every 6-8 hours (regular tablets) as needed for pain. Naprosyn may cause an upset stomach. Take Naprosyn with food or milk.

Warnings/Precautions

Before taking this medication, tell your doctor if you have an allergy to aspirin or any other NSAIDs, have an ulcer or bleeding in your stomach, drink more than three alcoholic beverages a day, have liver disease, Have kidney disease, have a coagulation (bleeding) disorder, have congestive heart failure, have fluid retention, have heart disease, or have high blood pressure. You may not be able to take Naprosyn or you may require a dosage adjustment or special monitoring during treatment if you have any of the conditions listed above. Naprosyn is in the FDA pregnancy category B. This means that it is not expected to be harmful to an unborn baby. Naprosyn should not be taken late in pregnancy (the third trimester) because a similar drug is known to affect the baby's heart. Do not take Naprosyn without first talking to your doctor if you are pregnant. Naprosyn passes into breast milk and may affect a nursing infant. Do not take this medicine without first talking to your doctor if you are breast-feeding a baby.

Missed Dose

If you are taking Naprosyn on a regular schedule, take the missed dose as soon as you remember. However, if it is almost time for the next dose, skip the missed dose and take only the next regularly scheduled dose. Do not take a double dose. If you are taking Naprosyn as needed, take the missed dose if it is needed, then wait the recommended or prescribed amount of time before taking another dose.

Possible Side Effects

Contact your doctor if you experience blood in vomit or bloody, black, or tarry stools. These symptoms could indicate damage to the stomach or intestines, which could be dangerous. If you experience any of the following serious side effects, stop taking Naprosyn and seek medical treatment or contact your doctor immediately: an allergic reaction (difficulty breathing; closing of the throat; swelling of the lips, tongue, or face; or hives); muscle cramps, numbness, or tingling; ulcers (open sores) in the mouth; rapid weight gain (fluid retention); seizures; decreased hearing or ringing in the ears; yellowing of your skin or eyes (jaundice); or abdominal cramping, heartburn, or indigestion. Other, less serious side effects may be more likely to occur. Continue to take Naprosyn and talk to your doctor if you experience dizziness or headache; nausea, diarrhea, or constipation; depression; fatigue or weakness; dry mouth; or irregular menstrual periods. Side effects other than those listed here may also occur. Talk to your doctor about any side effect that seems unusual or that is especially bothersome.

Storage

Store Naprosyn suspension at room temperature; avoid excessive heat, above 40°C (104°F). Dispense in light-resistant container. Store Naprosyn tablets at room temperature and in well-closed containers; dispense in light-resistant container.

Overdose

Significant over dosage may be characterized by drowsiness, heartburn, indigestion, nausea or vomiting, seizures. If you ingest a large number of tablets or a large volume of suspension, accidentally or purposefully consult a doctor, an emergency room, or a poison control left for advice.

More Information

Avoid prolonged exposure to sunlight. Naprosyn may increase the sensitivity of the skin to sunlight. Use a sunscreen and wear protective clothing when exposure to the sun is unavoidable. Avoid alcohol or use it with moderation. If you drink more than three alcoholic beverages a day, Naprosyn may increase the risk of dangerous stomach bleeding. Talk to your doctor before taking Naprosyn if you drink more than 3 alcoholic beverages a day. Use caution when driving, operating machinery, or performing other hazardous activities. Naprosyn may cause dizziness. If you experience dizziness, avoid these activities. Many over-the-counter cough, cold, allergy, and pain medicines contain aspirin or other medicines similar to Naprosyn. Before taking any prescription or over-the-counter medicine, talk to your doctor and pharmacist.

Disclaimer

This drug information is for your information purposes only, it is not intended that this information covers all uses, directions, drug interactions, precautions, or adverse effects of your medication. This is only general information, and should not be relied on for any purpose. It should not be construed as containing specific instructions for any particular patient. We disclaim all responsibility for the accuracy and reliability of this information, and/or any consequences arising from the use of this information, including damage or adverse consequences to persons or property, however such damages or consequences arise. No warranty, either expressed or implied, is made in regards to this information.

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Uterine Cancer Also called: Endometrial cancer The uterus, or womb, is an important female reproductive organ. It is the place where a baby grows when a women is pregnant. There are different types of uterine cancer. The most common type starts in the endometrium, the lining of the uterus. This type of cancer is sometimes called endometrial cancer. The symptoms of uterine cancer include * Unusual vaginal bleeding or discharge * Trouble urinating * Pelvic pain * Pain during intercourse Uterine cancer usually occurs after menopause. Being obese and taking estrogen-alone hormone replacement therapy also increase your risk. Treatment varies depending on your overall health, how advanced the cancer is and whether hormones affect its growth. Treatment is usually a hysterectomy, which is surgery to remove the uterus. Other options include hormone therapy and radiation. About the Uterus and Endometrium The uterus is a hollow organ, about the size and shape of a medium-sized pear. The uterus has two main parts. The lower end of the uterus, which extends into the vagina, is called the cervix. The upper part is the body of the uterus, also known as the corpus. (Corpus is the Latin word for body.) The body of the uterus has two layers. The inner layer is called the endometrium. (endo is Greek for inside and metrium is Greek for uterus.) The outer is called the myometrium. (myo is Greek for muscle.) The myometrium is the thick layer of muscle that pushes the baby out during birth. Hormone changes during a woman?s menstrual cycle cause the endometrium to change. During the early part of the cycle, the ovaries (glands on either side of the uterus that produce eggs) produce estrogens. This causes the endometrium to thicken in order to nourish an embryo in case the woman becomes pregnant. After an ovary releases an egg (called ovulation), if pregnancy does not occur, estrogen is produced in lower amounts and more progesterone is made. This causes the innermost layer of the lining to prepare to shed. By the end of the cycle, the lining is shed from the uterus and becomes the menstrual flow. This cycle repeats throughout a woman?s life until menopause (change of life). Cancers of the Uterus and Endometrium Adenocarcinomas: Nearly all endometrial cancers (about 95%) are cancers of glandular cells, called adenocarcinomas. Most of these are described as typical adenocarcinomas. Most experts divide endometrial adenocarcinomas into two types. In type 1, the cancer looks most like normal endometrium and may not be a very dangerous, life-threatening cancer. It only occasionally spreads to other tissues. This type is often called endometrioid, meaning it looks like normal endometrial lining tissue. There are three grades of tumor, with grade three being more aggressive with a greater risk of invasion to the uterine wall (myometrium), local and distant metastases. Sometimes, in addition to glandular cells, endometrial cancers also contain squamous cells (the type of cells found on the surface of the cervix and the skin). If the squamous cells look benign (non-cancerous) under a microscope and the glandular cells look cancerous, these tumors are called adenocarcinomas with squamous differentiation (they used to be called adenoacanthomas, although this term is now used much less often). If the squamous areas and glandular areas both look malignant (cancerous), these tumors are called adenosquamous carcinomas. Although these look different under the microscope, they are treated the same as typical endometrial adenocarcinomas. However, adenosquamous carcinomas tend to be more aggressive. Type 2 endometrial cancer doesn?t look at all like normal endometrium. It is much more likely to spread and is, therefore, more dangerous, These types are called either papillary serous adenocarcinomas or clear cell adenocarcinomas. About 10% of endometrial cancers are these types. Because they are different from the usual kind and tend to grow and spread they are treated more aggressively than the endometrioid cancers. Women with this type of cancer tend to be older by five to ten years on average, than women with type 1. Uterine sarcomas: Uterine cancers that do not come from glandular tissue of the endometrium are called uterine sarcomas. They are less common, but can still involve other parts of the endometrium. These include: * stromal sarcomas, which start in the stroma (supporting connective tissue) of the endometrium * malignant mixed mesodermal tumors (MMMTs or carcinosarcomas), which may combine features of endometrial carcinoma and those of sarcomas * leiomyosarcomas, which start in the myometrium or muscular wall of the uterus These three types of cancer are not discussed in this document because their treatment and prognosis (the outlook for survival) are different from the most common cancers of the endometrium. These cancers are discussed in the document ?Uterine Sarcomas,? which is available from the American Cancer Society upon request or online. Cervical cancers: Cancers of the cervix are different from cancers of the body of the uterus and are described in another American Cancer Society document.

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