Drug Uses

Lamisil Tablets are indicated for the treatment of onychomycosis of the toenail or fingernail due to dermatophytes.

How Taken

Lamisil comes as a tablet to take orally. It is usually taken once a day for 6 weeks for fingernail fungus and once a day for 12 weeks for toenail fungus. Take Lamisil exactly as directed. Do not take more or less of it or take it more often than prescribed by your doctor. Your fungus may not be completely cured until a few months after you finish taking Lamisil. This is because it takes time for a healthy nail to grow in.

Warnings/Precautions

Do not take Lamisil without first talking to your doctor if you have ever had an allergic reaction to it, liver disease, kidney disease, problems with your immune system, or blood problems. You may not be able to take Lamisil, or you may require a dosage adjustment or special monitoring if you have any of the conditions listed above. Lamisil is in the FDA pregnancy category B. This means that it is not expected to harm an unborn baby. Do not take Lamisil without first talking to your doctor if you are pregnant. Lamisil passes into breast milk and may affect a nursing baby. Do not take this medication without first talking to your doctor if you are breast-feeding a baby.

Missed Dose

Take the missed dose as soon as you remember. However, if it is almost time for the next regularly scheduled dose, skip the missed dose and take the next one as directed. Do not take a double dose of this medication.

Possible Side Effects

If you experience any of the following serious side effects, stop taking Lamisil and seek emergency medical attention: an allergic reaction (difficulty breathing; closing of your throat; swelling of your lips, tongue, or face; or hives); a rash; changes in vision; or blood problems (detected by blood tests). In rare cases, Lamisil has caused severe liver damage, sometimes resulting in liver transplant or death. Notify your doctor immediately if you develop nausea, vomiting, abdominal pain, unusual fatigue, loss of appetite, yellow skin or eyes, itching, dark urine, or clay colored stools. These symptoms may be early signs of liver damage. Other, less serious side effects may be more likely to occur. Continue to take Lamisil and talk to your doctor if you experience nausea, upset stomach, or heartburn; diarrhea or flatulence; headache; or taste disturbances or a loss of taste. Side effects other than those listed here may also occur. Talk to your doctor about any side effect that seems unusual or that is especially bothersome.

Storage

Store tablets below 25o C (77o F); in a tight container. Protect from light.

Overdose

Clinical experience regarding overdose with Lamisil Tablets is limited. The symptoms of overdose included nausea, vomiting, abdominal pain, dizziness, rash, frequent urination, and headache. Seek emergency medical attention.

More Information

Avoid alcohol or use it in moderation while taking Lamisil. Alcohol and Lamisil can both affect the liver. Lamisil Tablets are contraindicated if you have a hypersensitivity to Lamisil.

Disclaimer

This drug information is for your information purposes only, it is not intended that this information covers all uses, directions, drug interactions, precautions, or adverse effects of your medication. This is only general information, and should not be relied on for any purpose. It should not be construed as containing specific instructions for any particular patient. We disclaim all responsibility for the accuracy and reliability of this information, and/or any consequences arising from the use of this information, including damage or adverse consequences to persons or property, however such damages or consequences arise. No warranty, either expressed or implied, is made in regards to this information.

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Tretinoin, also known as all-trans-retinoic acid (ATRA), is a naturally occurring derivative of vitamin A (retinol). Retinoids such as tretinoin are important regulators of cell reproduction, proliferation, and differentiation and are used to treat acne and photodamaged skin and to manage keratinization disorders such as ichthyosis and keratosis follicularis. Tretinoin also represents the class of anticancer drugs called differentiating agents and is used in the treatment of acute promyelocytic leukemia (APL). For the the induction of remission in patients with acute promyelocytic leukemia (APL), French-American-British (FAB) classification M3 (including the M3 variant); For the topical treatment of acne vulgaris, flat warts and other skin conditions (psoriasis, ichthyosis congenita, icthyosis vulgaris, lamellar icthyosis, keratosis palmaris et plantaris, epidermolytic hyperkeratosis, senile comedones, senile keratosis, keratosis follicularis (Darier's disease), and basal cell carcinomas.); For palliative therapy to improve fine wrinkling, mottled hyperpigmentation, roughness associated with photodamage.
Tretinoin binds to alpha, beta, and gamma retinoic acid receptors (RARs). RAR-alpha and RAR-beta have been associated with the development of acute promyelocytic leukemia and squamous cell cancers, respectively. RAR-gamma is associated with retinoid effects on mucocutaneous tissues and bone. Although the exact mechanism of action of tretinoin is unknown, current evidence suggests that the effectiveness of tretinoin in acne is due primarily to its ability to modify abnormal follicular keratinization. Comedones form in follicles with an excess of keratinized epithelial cells. Tretinoin promotes detachment of cornified cells and the enhanced shedding of corneocytes from the follicle. By increasing the mitotic activity of follicular epithelia, tretinoin also increases the turnover rate of thin, loosely-adherent corneocytes. Through these actions, the comedo contents are extruded and the formation of the microcomedo, the precursor lesion of acne vulgaris, is reduced. Tretinoin is not a cytolytic agent but instead induces cytodifferentiation and decreased proliferation of APL cells in culture and in vivo. When Tretinoin is given systemically to APL patients, tretinoin treatment produces an initial maturation of the primitive promyelocytes derived from the leukemic clone, followed by a repopulation of the bone marrow and peripheral blood by normal, polyclonal hematopoietic cells in patients achieving complete remission (CR). The exact mechanism of action of tretinoin in APL is unknown.

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